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pentobarbital will lessen the extent or effect of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Solid or average CYP3A4 inducers noticeably lessen guanfacine plasma concentrations and elimination 50 percent-lifestyle.pentobarbital will lessen the level or impact of disopyramide by influe

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